Anne Grippo - Professor of Biological Sciences

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Phone: 870-972-3493 (Office)
Address: Arkansas State University I PO Box 599 I State University AR 72467
Email: agrippo@astate.edu

Affiliations:

Arkansas State University, Arkansas Biosciences Institute

Cluster Identification:
- Plant Interactions with Other Organisms Cluster

Research Areas/Expertise:
- Antioxidants
- Phytochemicals & Human Health
- Plant-Made Industrial/ Pharmaceutical Proteins

Research Summary | Selected Publications | Lab Members | Key Collaborators | Research Projects | Links

 

Research Summary | Selected Publications | Lab Members | Key Collaborators | Research Projects | Links

Research Summary:

Our P3 project focused on foods that would provide feasible and cost-effective alternative/adjunctive therapies to patients with chronic inflammatory-related disorders.  The overall objective of this study was to use an animal model of inflammation to bring forth evidence that plant-based anti-inflammatory agents such as resveratrol and anthocyanins reduce inflammation and thereby prevent the development of atherosclerosis.  This is important to the health of menopausal women who have lowered estrogen levels, because after menopause, women experience a drastic increase in the risk of developing cardiovascular disease, often due to the development of atherosclerosis.  Atherosclerosis, which may in part be mediated by elevated levels of serum cholesterol, is the primary cause of cardiovascular disease. Our central hypothesis is that plant-based anti-inflammatory agents reduce inflammation and thus prevent inflammatory-induced chronic diseases, such as cardiovascular disease. 

For this study, we utilized female Sprague-Dawley (SD) rats that were either Sham-operated or Ovariectomized (Ovx).  Several studies have shown that estrogen depletion can cause chronic inflammation in this animal model.  Rats were fed either a high fat diet or a blueberry diet containing naturally-occurring anthocyanins.  Inflammatory response markers were measured in several tissues to determine whether the blueberry diet decreased the cardiovascular inflammatory response associated with lowered estrogen levels.

Selected Publications:

Brown CE, SE Trauth, RS Grippo, BJ Gurley, AA Grippo.  2012.  Combined Effects of Ephedrine-Containing Dietary Supplements, Caffeine, and Nicotine on Morphology and Ultrastructure of Rat Hearts.  J Caff Res.  Accepted for publication.

Shannon, J, J Shannon, S Modelevsky, AA Grippo.  2011.  Bisphosphonates and osteonecrosis of the jaw.  Amer. J. Ger. Pharmacother.    J Am Geriatr Soc 59:2350–2355, 2011.

Grippo, AA, K Capps, B Rougeau, BJ Gurley.  2007.  Analysis of flavonoid phytoestrogens in botanical and ephedra-containing dietary supplements.  Ann. Pharmacother.  41:1375-82.

Grippo, AA, B Hamilton, R Hannigan, BJ Gurley. 2006. Metal content of ephedra-containing dietary supplements and other select botanicals.  Am. J. Health Syst. Pharm. 63:635-644. 

Lab Members:

 


Anne Grippo, PhD,
Associate Professor of Biological Sciences
Arkansas Biosciences Institute and Department of Biological Sciences
agrippo@astate.edu ; 870-972-3493 

  Former Lab Students on P3 Research:

Yiou Wang
M.S. Biology Student
Department of Biological Sciences

 

Caleb Guthrey
Undergraduate Student
Department of Biological Sciences

 

Brandon Montalvo
Undergraduate Student
Department of Biological Sciences

 

Dustin Smith
Undergraduate Student
Department of Biological Sciences

Key Collaborators

Rebecca Parr, PhD I Biotechnology Program, Arkansas State University
Latha Devareddy, PhD I (former) Food Science, University of Arkansas, Fayetteville

Research Projects

Coming Soon

Links